Foundations in Cancer Genetics and Genomics

Course Overview and Description

Course Overview

This course introduces learners to the foundational principles of human genetics and genomics, with a particular focus on how these concepts inform our understanding of cancer. Through a blend of scientific theory and real-world clinical insight, students will explore how genetic variation contributes to disease susceptibility, prognosis, and the development of precision oncology strategies. The course draws on high-impact research from across the world and equips students with the tools to critically interpret genomic data relevant to oncology and human health.

 

Course Description

This module explores the architecture of the human genome and the functional consequences of genetic variation, with a dedicated emphasis on cancer genetics and molecular oncology. Students will examine how inherited and somatic mutations influence gene expression, tumour development, and patient response to treatment.

 

The course includes:

  • The structure and regulation of the human genome, including genes, non-coding DNA, regulatory elements (enhancers, silencers), and epigenetics.
  • Types of genomic variation (SNPs, indels, CNVs, rearrangements) and their biological significance.
  • Cancer-specific mutations in oncogenes and tumour suppressor genes (e.g.,TP53BRCA1).
  • An introduction to genotype–phenotype relationships, variable expressivity, and penetrance in disease.
  • Landmark studies including insights from the 1000 Genomes Project, Cancer Genome Atlas, and recent breakthroughs in CRISPR and RNA therapeutics.

 

We reference the groundbreaking work of internationally recognised researchers such as:

  • Francis Collins (National Institutes of Health, USA) & Eric Lander (Broad Institute of MIT and Harvard) Human Genome Project
  • Jennifer Doudna (University of California, Berkeley) & Emmanuelle Charpentier (Max Planck Institute for Infection Biology)  CRISPR genome editing
  • Katalin Karikó & Drew Weissman (University of Pennsylvania, Nobel Prize 2023)  RNA therapeutics and mRNA vaccine development
  • Mary-Claire King (University of Washington)  Discovery of BRCA1 and the genetics of breast cancer
  • David Reich (Harvard University)  Population genomics and ancient DNA
  • Sir Mark Caulfield (Queen Mary University of London & NHS Genomic Medicine Service)  National implementation of genomic medicine in the UK

 

The individuals and organisations listed are referenced solely to highlight the groundbreaking scientific advances that inspire and shape the academic vision of the Oxford Academy of Excellence. While there is no formal affiliation, our curriculum is designed with the same level of ambition, rigour, and global relevance — reflecting the pioneering standards set by these world-leading researchers and institutions.

 

Learning Outcomes

By the end of the course, students will be able to:

  • Describe the fundamental structure of the human genome and identify key genomic features.
  • Analyse different forms of genetic variation and their relevance in cancer biology.
  • Understand the principles of gene regulation and epigenetic control in normal and malignant cells.
  • Explain how genomic data informs cancer diagnosis, prognosis, and treatment.
  • Use publicly available genomic resources (e.g., Ensembl, gnomAD) to interpret basic genomic data.
  • Evaluate the impact of global genetic diversity on health and disease.

Program Structure

At the Oxford Academy of Excellence, each programme is shaped by global educational excellence, combining academic depth with real-world relevance. Our model draws on world-leading pedagogical approaches and is continually informed by pioneering work from institutions such as Harvard, MIT, Oxford, and Stanford, as well as insights from global industry leaders and Nobel Prize-winning research.

 

This structure is designed to be cross-disciplinary, supporting students in fields ranging from health sciences and engineering to sustainability, policy, and innovation. Whether learners aspire to careers in science, technology, entrepreneurship, or public service, they are equipped with the skills, mindset, and knowledge to lead with impact.

 

1. Self-Paced Foundation Modules.

Programmes begin with flexible, high-quality learning modules that build a strong knowledge base. These include:

  • Faculty-led videos from global experts
  • Real-world multimedia cases and readings
  • Interactive quizzes and reflective tasks
  • This phase supports independent learning while building confidence in core concepts.
 

2. Live, Case-Based Mentorship Sessions

Learners engage in mentor-guided workshops focused on applied learning, featuring:

  • Cross-disciplinary case challenges
  • Group problem-solving and simulations
  • Feedback from expert facilitators, researchers, or professionals
    These sessions promote critical thinking, collaboration, and strategic communication.

 

3. Agile, Global-Relevance Curriculum

Every programme is regularly updated to reflect:

  • Breakthroughs in science, technology, and society
  • Input from academic reviewers, mentors, and students
  • Insights from global institutions and innovation ecosystems, including leaders from companies such as Genentech, DeepMind, Google Health, and policy networks like the WHO and the UN

This ensures that all learning remains relevant, future-proof, and adaptable to the changing needs of the world.

Teaching and Assessment Approach

At the Oxford Academy of Excellence, teaching is built on world-class educational design—drawing from the pedagogical practices of institutions such as Harvard, Oxford, and MIT, and guided by frameworks from UNESCO, QAA, and the World Economic Forum. Each course offers an immersive learning experience, led by global experts and shaped by the demands of real-world innovation.


Our teaching philosophy blends academic excellence with transformative, hands-on learning. Students are empowered to think critically and creatively, solve complex interdisciplinary challenges, communicate with clarity and empathy, collaborate across diverse sectors, and reflect on their development and impact.


Teaching methods include case-based masterclasses with leading academics and professionals, live interactive labs, ethical simulations, and leadership challenges. Personalised mentorship aligns with each student’s goals, while interdisciplinary projects are informed by real research and current industry trends.


Assessment is designed not only to evaluate learning but to transform thinking and practice. Students may be assessed through critical reflections, research reviews, practical prototypes, impact reports, peer feedback, oral defences, and innovation sprints. Final outputs often include a portfolio, publication, or policy brief, supported by tailored feedback from a globally recognised mentor.


This approach ensures that students complete their programme with a tangible outcome and a skillset aligned with the world’s most in-demand careers—ready to lead, create, and contribute across science, society, and beyond.

What Sets this Program Apart

A Rigorous, Research-Led Foundation in Genomics and Cancer

This course bridges foundational human genetics with the evolving field of cancer genomics, offering learners an opportunity to explore how genomic science transforms our understanding of health and disease. Drawing on Nobel Prize-winning discoveries and high-impact research from the Human Genome Project to CRISPR-based gene editing the programme connects core molecular principles with cutting-edge developments in precision oncology. Learners engage with content inspired by global leaders in biomedical science, including work from Harvard, the NHS Genomic Medicine Service, and the Cancer Genome Atlas.

 

Mentorship by International Experts

Students benefit from personalised mentorship by educators and researchers with advanced training in genomic medicine, cancer biology, and translational research. One-to-one academic support replicates the depth of elite research environments, nurturing each learner’s ability to interpret genomic data, formulate questions, and apply theoretical concepts to clinical and real-world settings. This tailored supervision enhances both scientific reasoning and academic confidence.

 

Clinical Relevance and Future Career Alignment

Designed in response to the increasing demand for genomic literacy in healthcare and biomedical research, the course builds essential skills for roles in medicine, biotechnology, and bioinformatics. From understanding inherited mutations (e.g. BRCA1TP53) to exploring the therapeutic potential of RNA and genome editing technologies, students gain insight into how genomic data directly informs diagnostics, prognostics, and treatment decisions preparing them for future academic progression, research opportunities, or early-stage careers in precision medicine.

 

Pathways to Academic Recognition and Real-World Impact

Students have the option to undertake guided research or analysis projects using real genomic datasets and publicly available tools (e.g., Ensembl, gnomAD, UCSC Genome Browser). These activities foster practical skill-building and can form the basis for university applications, competitions, or independent publication. Upon completion, learners receive a certificate and a personalised academic reference from a senior faculty member supporting their advancement into competitive programmes or roles across genomic science, clinical research, or higher education.

 

Programme Highlights

• Become a published co-author of a professionally curated academic book in genetics or oncology
• Write and publish a scientific article under expert supervision, with opportunities for dissemination through recognised platforms
• Analyse real-world cancer genomics data using tools such as Ensembl, gnomAD, and the UCSC Genome Browser
• Receive personalised mentorship from senior academics with expertise in genomics, precision medicine, and translational oncology
• Gain a Certificate of Excellence and an academic reference letter to strengthen applications for research posts, fellowships, or advanced study

Foundations in Cancer Genetics and Genomics

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